Intrinsic D614G and P681R/H mutations in SARS-CoV-2 VoCs Alpha, Delta, Omicron and viruses with D614G plus key signature mutations in spike protein alters fusogenicity and infectivityArticle Published on 2023-02-012023-07-11 Journal: Medical Microbiology and Immunology [Category] COVID19(2023년), [키워드] Delta Infectivity omicron SARS-CoV-2 variants of concern Virus entry. [DOI] 10.1007/s00430-022-00760-7 PMC 바로가기
Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody neutralizing antibody. omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 InfectionSARS-CoV-2 감염 시 인테그린과 캐드헤린 간의 분자 상호작용으로 혈관 장벽 무결성 상실Article Published on 2022-04-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] abnormal coagulation barrier cadherin candidate cilengitide complex Complication contribute COVID-19 Cytokine storms dysregulation Effects elicit endothelial endothelial cells Endothelial dysfunction Endotheliitis event events expressed Extracellular homeostasis Hypoxemia inhibitor integrin integrin αVβ3 Integrins integrity internalization intracellular signaling life-threatening Loss mechanism motif multiple organ failure Pathways peptide phenotype phlogistic prevented Protein receptor redistribution RGD motif SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Spike protein Support the spike protein thrombotic Thrombotic complications Trigger Vascular vascular dysfunction vascular dysfunction. vascular leakage [DOI] 10.3390/v14050891 PMC 바로가기 [Article Type] Article
Sex, Age, and Ethnic Background Shape Adaptive Immune Responses Induced by the SARS-CoV-2 mRNA VaccineOriginal Research Published on 2022-03-282023-06-14 Journal: Frontiers in Immunology [Category] MERS, SARS, [키워드] antigen-specific T cell response HLA mRNA vaccine SARS-CoV-2 SARS-CoV-2 variants of concern T peripheral helper cell [DOI] 10.3389/fimmu.2022.786586 PMC 바로가기 [Article Type] Original Research
Importation, circulation, and emergence of variants of SARS-CoV-2 in the South Indian state of KarnatakaResearch Article Published on 2022-02-072022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] acute respiratory syndrome amino acid changes amino acid replacement Analysis B.1 B.1.1.7 B.1.351 Brazil changes in circulating circulation coronavirus coronavirus disease COVID-19 COVID-19 India Critical distribution fraction Genomic epidemiology genomic variant Immune escape India International introduced Karnataka Lineage lineages Local MONITOR nine outbreak Outbreak investigation pandemic performed positive Re-infection reported SARS-CoV-2 SARS-CoV-2 spread SARS-CoV-2 variants of concern sequenced severe disease South South Africa south India Spread Support the study group Transmission Travel variant variants variants of concern variants of SARS-CoV-2 virus VoC whole genome [DOI] 10.12688/wellcomeopenres.16768.2 PMC 바로가기 [Article Type] Research Article
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccinationArticle Published on 2022-01-252023-06-16 Journal: Cell [Category] MERS, SARS, [키워드] antibodies Astra Zeneca Autopsy BBIBP-CorV BioNTech-Pfizer BNT162b2 ChAdOx1-S COVID-19 delta variant Endemic coronaviruses Gam-COVID-Vac Imprinting lymph node germinal center Moderna mRNA-1273 SARS-CoV-2 SARS-CoV-2 variants of concern Sinopharm Sputnik V Vaccine [DOI] 10.1016/j.cell.2022.01.018 PMC 바로가기 [Article Type] Article
Developing an Amplification Refractory Mutation System-Quantitative Reverse Transcription-PCR Assay for Rapid and Sensitive Screening of SARS-CoV-2 Variants of ConcernSARS-CoV-2 변이체의 신속하고 민감한 스크리닝을 위한 증폭 불응 돌연변이 시스템-정량적 역전사-PCR 분석법 개발Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha alpha and delta variants amplification analyzed application ARMS ARMS-RT-qPCR B.1.617.2 clinical sample clinical samples concern concerning conserved conserved unique mutation coronavirus Delta delta variant Delta variants demonstrated detect develop Developing fluorescent Genome genomes Genomic analysis GISAID hospital Laboratory Lineage lineages Molecular assay Molecular diagnosis Mutation network organizations pandemic PCR position Quantitative quantitative reverse transcription-PCR Rapid reagent reagents refractory respiratory reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Screening sensitive sequencing-based methods severe acute respiratory syndrome Coronavirus Spread target Transmission unique variant variants of concern VoC VOCs whole-genome sequencing [DOI] 10.1128/spectrum.01438-21 PMC 바로가기 [Article Type] Research Article
Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice변종 SARS-CoV-2 mRNA 백신은 마우스에서 1차 또는 부스터 시리즈로 광범위한 중화를 부여합니다.Article Published on 2021-12-172022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] (Beta) 1:1 acute respiratory syndrome acute respiratory syndrome coronavirus animals Antibody titers B.1.351 Beta booster booster dose causative agent Clinical studies coronavirus COVID-19 COVID-19 disease COVID-19 vaccine demonstrated dose effective Efficacy ENCODE evaluated global pandemic initial mice mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273. mRNA-1273.211 mRNA-1273.351 neutralization neutralization titers Neutralizing antibody titer neutralizing antibody titers Primary series respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly increased Spike protein susceptibility symptomatic COVID-19 disease the spike protein vaccination Vaccine vaccine efficacy Vaccine-induced immunity variant Viral viral escape wild-type [DOI] 10.1016/j.vaccine.2021.11.001 PMC 바로가기 [Article Type] Article
SARS-CoV-2 mRNA vaccine BNT162b2 triggers a consistent cross-variant humoral and cellular responseSARS-CoV-2 mRNA 백신 BNT162b2는 일관된 교차 변형 체액 및 세포 반응을 유발합니다Observational Study Published on 2021-12-012022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 임상, 진단, 치료기술, [키워드] administration all subject Alpha antibody Antibody Response Antibody titre B.1 B.1.1.7 B.1.351 B.1.525 B.1.617.2 Beta BNT162b2 BNT162b2 vaccine cellular response chemiluminescence immunoassay CLIA CLIA assay CLIA assays Cohort correlation Definition Delta dose Efficacy elicited Eta evaluated Gamma HCW HCWs Health care Health care worker humoral Humoral response immune evasion immune response immunoassays in vitro mRNA vaccine Neutralization assay Neutralizing activity NTA observé P.1 pandemic Protective protective neutralizing antibody provided quantity reliability robust SARS-CoV-2 SARS-CoV-2 bnt162b2 mRNA vaccine SARS-CoV-2 pandemic SARS-CoV-2 variants SARS-CoV-2 variants of concern strain Strains T-cell mediated respone T-cell Response tested the SARS-CoV-2 Trigger vaccinal vaccination variants of concern VoC [DOI] 10.1080/22221751.2021.2004866 PMC 바로가기 [Article Type] Observational Study
Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 VariantsSARS-COV-2 변이체에 대한 mRNA-1273의 혈청 중화 활성Clinical Trial Published on 2021-09-222022-08-13 Journal: Journal of Virology [Category] MERS, SARS, 변종, 임상, 진단, [키워드] (alpha (Beta activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.7 B.1.351 B.1.351-v1 B.1.351-v2 B.1.351-v3 B.1.617.2 Beta coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine D614G Delta Effect elicited expected fold Gamma Immunity immunization immunized mRNA mRNA-1273 mRNA-1273 COVID-19 vaccine neutralization neutralization titer neutralization titers Neutralizing activity Neutralizing antibodies neutralizing antibody P.1 participant Protective reduction remained respiratory Result SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 variants of concern SARS-CoV-2 virus sera Serum Neutralization severe acute respiratory syndrome Coronavirus significantly statistically susceptible tested Transmissibility Vaccination strategy Vaccine variant variants variants of concern variants of interest variants of SARS-CoV-2 virus VOCs VOIs was reduced while wild-type SARS-CoV-2 wild-type virus [DOI] 10.1128/JVI.01313-21 PMC 바로가기 [Article Type] Clinical Trial